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Other enzymes using glutathione as a substrate are glutaredoxins

Some clinical studies have shown that pioglitazone treatment (30 mg/day, P.O for 4 weeks) exhibits antioxidant properties in diabetic patients, as reflected by a decrease in MDA [218, 219]

Frontiers in neural circuits, 2023

When you have adequate levels of glutathione in your system, it prevents damage to these organs caused by excessive amounts of acetaldehyde

Schmied A, Marske L, Berger M et al (2023) Human biomonitoring of deoxynivalenol (DON) - assessment of the exposure of young German adults from 19962021

Although these findings indicate that the regulation of ferroptosis by Nrf2 in lung diseases may be related to the inhibition of mitochondrial ROS, further validation studies are necessary