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Iglesias et al., 2004

As a result, it causes immune-mediated enteropathy, intestinal inflammation, followed by the atrophy of villi, crypt hyperplasia and increased infiltration by intraepithelial lymphocytes [11]

It is central to: Detoxification: Neutralizing free radicals and heavy metals Immune defense: Maintaining lymphocyte and macrophage function Redox homeostasis: Regulating disulfide bonds and antioxidant recycling Cellular repair: Protecting lipid membranes and mitochondrial DNA Despite its significance, traditional glutathione supplements face major limitations: Poor intestinal absorption Rapid breakdown into constituent amino acids Minimal rise in systemic glutathione levels Weak clinical outcomes This gap between glutathiones potential and its real-world efficacy is what motivated the move toward liposomal delivery systems

doi: 10.1038/ncpendmet0424 38 ShahidMAAshrafMASharmaS

Tauffenberger et al., 2019

They also identified proteins associated with the extracellular matrix including cytokines, fibronectin, tenascin, and OPN