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Bidirectional regulation of NF-B by reactive oxygen species: a role of unfolded protein response

In: Greenspan's Basic & Clinical Endocrinology

For example, manganese superoxide dismutase (MnSOD), a mitochondrial antioxidant enzyme, can undergo nitration of its tyrosine residues, leading to enzyme inactivation and contributing to oxidative stress and related diseases

For selenocysteine, incorporation occurs at UGA stop codons (Chambers et al

In 8 out of 10 countries investigated in that study (Vicedo-Cabrera et al., 2018), the fraction of deaths attributable to heat declined over time, and this decline was due mostly to decreased sensitivity to heat (i.e., not local cooling)

From the view of the cytokine profile of IgG4-RD includes Th2 cytokines (IL-4, IL-5, and IL-13) and regulatory cytokines (IL-10 and tumor growth actor [TGF]-), the Th2 immune response play a key role in the pathophysiology of type1 AIP including IgG4-RD [76,77,78,79]