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Interestingly, FOXO4-DRI did not affect cell viability in PDL3 group (Supplementary Figures 1, 2)

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This presents issues in data generalisability to the wider population, which should be addressed in future by the use of more diverse cohorts

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However, the field faces challenges, including the need for a deeper understanding of the molecular underpinnings of SIRT1s role in ferroptosis and the development of targeted therapies that can effectively harness this enzymes activity