what causes melanotic macule

what causes melanotic macule Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Labial melanotic macule (brown spot

Name: what causes melanotic macule Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Labial melanotic macule (brown spot
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Labial melanotic macule (brown spot on lip) (Stony Brook Case 1) dermatology dermatopathology Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Mucosal melanocytic macules Oral pigmented lesions: Clinicopathologic features and review of the literature PMC Melanotic macules of the tongue in a newborn Journal of the American Academy of Dermatology Citalopram Induced Oral Melanotic Macules in a Female Patient and a Review of the Literature Cureus

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The different types of disease-associated melanoses listed below are highly correlated with oral/perioral pigmentation and are of prime concern in a differential diagnosis: Addisons disease Peutz-Jeghers syndrome Chronic lichen planus Laugier-Hunziker syndrome Neurofibromatosis McCune-Albright syndrome Kaposi sarcoma The prognosis for oral melanotic macules is excellent, and they are followed and monitored after diagnosis through documentation and photographs/images

Numerous researches have reported that silibinin can promote the apoptosis by regulating apoptotic-related proteins (e.g., Bax, Bcl-2, and Bcl-xL) and activating Caspases in lung, colon, renal, oral, pancreatic cancers, as well as endometrial carcinoma [920, 921]