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doi: 10.1016/j.jep.2021.114647 89

Iron-chelating and ros-scavenging polymers with thioketal and thioether bonds delivering ferroptosis inhibitor lip-1 provide a triple therapeutic strategy for retina ganglion cells in acute glaucoma

To investigate their biogenesis, we perform cryo-electron microscopy and liposome tubulation assays, showing that Arabidopsis SNX1 generates shorter membrane tubules than its mammalian counterpart, consistent with reduced membrane affinity linked to differences in the amphipathic helix

explored the different binding modes of the pyrimidinone scaffold through cocrystal structures of cpds

Glutathione plays a central role in the bodys antioxidant defense systems and helps support cellular protection and normal detoxification processes

additionally, NMN treatment led to reduced mitochondrial ROS production and enhanced oxygen consumption rate 112