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However, delayed treatment after hepatic injury presents a variable prognosis, and progression to hepatic failure carries a mortality rate of 20% to 40%

J Comput Chem 14:13471363

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Significantly, the hexahydropyridine ring exhibited substantially better activity than the pyridine ring, while the pyrrole ring outperformed the tetrahydropyrrole ring ( In a molecular hybridization approach, the 3-O-(3,4,5-trimethoxycinnamoyl) derivative (Figure 1d) exerted its effect through a unique non-nucleoside mechanism by interfering with the transcriptional regulation of the HBV X promoter and enhancer I, achieving a 16-fold increase in DNA replication inhibitory activity (IC 50 = 2.44 M) compared to the parent compound (Wang et al., 2012a)