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Response: We appreciate and acknowledge these comments related to the implementation of the transfer of care modifiers proposal

The safety of long-term concurrent use has not been evaluated

In preclinical toxicity studies, no lethal dose has been identified (meaning researchers could not find a dose high enough to cause death in animals), and few side effects have been reported in animal models

After 2 h of adding the MTT reagent, the cells were dissolved in DMSO, and the absorbance of the developed colored complex was measured at 570 nm

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Cytokine Growth Factor Rev 22:189195