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Abstract Resistance to neoadjuvant chemoradiation therapy, is a major challenge in the management of rectal cancer

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doi: 10.1016/j.molmet.2016.12.001 85 van RensburgMJvan RooyMBesterMJSeremJCVenterCOberholzerHM

In the classical pathway, the phosphorylation of IKK at Ser177 and Ser181, through the co-localization with TGF-beta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase 3 (MEKK3), promotes the phosphorylation of IBs, triggering their ubiquitination and degradation to worsen the NF-B cascade [3, 8, 9]