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4.3 Renal fibrosis and extracellular matrix remodeling Renal fibrosis is the common pathological endpoint of various chronic kidney diseases (CKD) and is characterized by fibroblast activation, epithelial-to-mesenchymal transition (EMT), and abnormal accumulation of the extracellular matrix (ECM), ultimately leading to nephron destruction and loss of function ( -SMA and collagen I, promoting interstitial remodeling

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DNA-bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma

Inulin balances the gut flora and may reduce intestinal inflammation, among other health benefits

Interestingly, men with distal chromosome 15 structural abnormalities are more likely to experience cryptorchidism, and this appears to involve the IGFR locus (92)