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For example, polyphenols and adaptogens within these herbs can enhance nuclear factor erythroid 2related factor 2 (Nrf2) activity, reduce reactive oxygen species (ROS), and normalize nitric oxide signaling, thereby removing epigenetic and post-translational blocks on HIF-1 stabilization and VEGF release

Inhibition of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) NOX is a plasma membrane-bound enzymatic complex that catalyzes the production of superoxide from oxygen and NADPH and has been involved in innate immune defense against microbes (39)

Gene regulation in Borrelia burgdorferi

Glutathione is most concentrated in the animal liver (10 mM), where the P450 Phase II enzymes require it to convert fat-soluble substances into water-soluble GSH conjugates in order to facilitate their excretion

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