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The decreased in vivo clearance of CYP2D6 substrates by CYP2D6 * 10 might be caused not only by the low-expression but also by low affinity of CYP2D6

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The blend is sold and studied as research-use-only material

Really the only Hashimotos patients who experience issues with goitrogens are those who are already deficient in iodine or those who are consuming massive quantities of goitrogenic compounds (this is rare)