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Taken together, the isotope labelling experiments prove that lysine degradation as depicted in Fig

Gray HJ, Bell-McGuinn K, Fleming GF, Cristea M, Xiong H, Sullivan D, et al

Mechanistically, ImP disrupts insulin receptor signaling by inhibiting the PI3K/AKT pathway, leading to prolonged activation of the FOXO1 (forkhead box protein O1) transcription factor [128]