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R.et al (2003)

Affiliation: 1 Centre for Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education & Research, Mysore 570015, Karnataka, India These authors contributed equally to this work

This age-related decline in immune function, called immune senescence, leads to alterations in the cytokine microenvironment as well as impaired innate and adaptive immunity and is closely related to oxidative stress (149)

This effect of AMPK signaling is in agreement with our previous studies showing that, despite having 15% and 40% of WT total and mitochondrial GSH levels (respectively), livers from nave GCLM KO mice maintain structural and functional integrity of the mitochondria and show induction of ER stress-related genes 17,38

(PubMed) Clarke JD, Hsu A, Riedl K, et al

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