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4H syndrome gene panel #AffordableHealthCare and Blue Light exposure that4H Syndrome Gene Panel Overview The 4H Syndrome Gene Panel is a genetic test used to identify mutations associated with 4H syndrome, a rare inherited neurological disorder. The name 4H stands for Hypomyelination, Hypodontia, and Hypogonadotropic Hypogonadism. This condition primarily affects the brain's white matter, dental development, and hormonal function. Genes Analyzed The panel typically includes: POLR3A POLR3B POLR1C POLR3K (where clinically