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Table 1 Role of kinases in OR desensitization/tolerance

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Adv Mater 26(5):805809

The exclusion criteria were: females who were pregnant or experiencing a menstrual period, type 2 diabetes treated using an insulin regimen, malignancy, hematopathy, active tuberculosis, peptic ulcer with gastric bleeding, binge-eating disorder, psychiatric disease, congestive heart failure, clinically relevant renal or hepatic insufficiency, unstable coronary artery disease, cancer or a history of cancer

mtROS-mediated oxidative damage results in cysteine residues within the mitochondrial calcium uniporter (MCU) becoming cysteinylated with S-glutathione, assembling the MCU channel into persistently active higher-order complexes, and promoting sustained mitochondrial calcium uptake [92]

These effects can further reduce neuron damage and apoptosis