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Improvement in the water solubility of drugs with a solid dispersion system by spray drying and hot-melt extrusion with using the amphiphilic Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer and d -mannitol

The magnesium and selenium contained in it also serve as muscle protection

Soto and Howell, 2014)

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A possible explanation for this absence of beneficial effects could be its low oral bioavailability or its complex intestinal absorption