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We note that if CMS were to implement new AMP reporting requirements in future policymaking, CMS would likely explore an approach that would allow the agency to recalculate the benchmark period manufacturer price if a manufacturer reported AMP data for the period described at 428.202(c)(1) or (2), as discussed above

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NaBPC157 (10 g or 10 ng/kg b.w., i.p.) or saline (5.0 ml/kg b.w., i.p.) was applied either 1 hour before or 1 hour after both carotid arteries were ligated for 3 or 6 hours in rats