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Pharmacokinetic and clinical studies with levocarnitine injection have shown that administration of levocarnitine to ESRD patients on hemodialysis results in increased plasma levocarnitine concentrations

In addition, it can result in seizures in individuals with seizure disorders and muscle weakness in those with uremia [10]

The free carnitine is transported to the cytosol by the CAC, and it can be recycled by CPT 1

In another study, glycolytic enzyme enolase 1 (ENO1), and in turn glycolysis, were increased in cisplatin resistant gastric cancer cells, which could be targeted by the glucose analog 2-DG (Qian et al., 2017)

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Here are a few reasons for this: Proteolysis (protein digestion): Protein digestion is likely to be impaired in hypothyroidism, but tends to be accelerated in hyperthyroidism