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doi: 10.1016/S1474-4422(07)70104-7 30 AlpertJEMischoulonDNierenbergAAFavaM

A significant negative latitude-dependent relationship was detected for carriage of the T allele, with occurrence of the cSHMT-C1420T polymorphic allele decreasing with increase in latitude ( r 2 =0.73, p 3R frequency in reported African and Eurasia studies found a significant negative relationship between latitude and frequency of the 3R allele ( r 2 =0.12, p =0.039) (Fig

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