acetaminophen overdose napqi glutathione mechanism authoritative source metabolism and NAPQI-mediated mitochondrial effects Acetaminophen – metabolism
Acetaminophen metabolism Xia & He Publishing Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential ScienceDirect Pharmacokinetic profile of metabolites by heart cutting two dimensional liquid chromatography: A focus on paracetamol analysis ScienceDirect Acetaminophen metabolism. Acetaminophen is metabolized primarily by sulfation and glucuronidation. However, it can also be oxidized by CYPs to form NAPQI. NAPQI can then interact with cellular macromolecules, resulting in toxicity, or it can be detoxified The conjugation of acetaminophen by glutathione and cytochrome P450. Download Scientific Diagram
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