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In the Y-maze, mice that were injected with AAV-Cre-GFP exhibited impaired spatial working memory, as evidenced by a reduced spontaneous alternation rate in the Y-maze test compared to control mice injected with AAV-GFP (Fig

Two hours post-surgery, mice were administered treatments via caudal vein injection

Hepatology 71, 15751591

133 , e162190 (2023)

High amounts of cholesterol can be stored in lipid rafts in the cell membrane and are involved in signaling pathways that support tumor growth and survival [34, 35]

We observed evidence of increased lipid peroxidation, a ROS by-product, in both BWS patient hepatocytes as well as in our BWS iPSC-hepatocyte model