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PMID: 15712276

In earlier work, Sekhars group had shown that in healthy adults, the levels of oxidative stress, oxidative damage and glutathione remain stable until people enter their 60s, when oxidative stress and oxidative damage begin to increase and glutathione to decline

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This results in suboptimal drug concentrations in the CNS that cannot completely suppress viral activity and may contribute to the selection of resistant mutations

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