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doi: 10.1016/j.jprot.2018.09.012 166 Shirazi ParsaH.SabetM
FIGURE 2 3.1 Gut-immune axis The gut microbiota plays a critical role in the development and regulation of the host immune system through metabolites such as SCFAs contributes to host immune regulation via multiple mechanisms-including G-protein couples receptor (GPCR) signaling (e.g., GPR43/41), histone deacetylase (HDAC) inhibition and cytokine modulation-one of which involves the context dependent balance of Th17 and regulatory T (Treg) cells to support immune homeostasis in physiological states (83, 84) and diseases like rheumatoid arthritis (RA) or autoimmune hepatitis (AIH) (85, 86)
We found a reasonable number of genes unique to the species or the phylum (8,023 genes
1002-A IMMUNE MODULATION OF T CELLS IN THE LIVER ALLOGRAFT REVEALED BY SINGLE-CELL SEQUENCING IN CYNOMOLGUS MONKEY MODEL Hiroshi Sakai 1,2 , Erik Berglund 1 , Sulemon Chaudhry 1 , Yojiro Kato 1 , Erin Duggan 1 , Joshua Weiner 1 , Paula Alonso-Guallart 1 , Nathaly Llore 1 , Karina Bruestle 1 , Jeffrey Stern 1 , Benjamin Piegari 1 , Dilrukshi Ekanayake-Alper 1 , Mercedes Martinez 3 , Genevieve Pierre 1 , Diane Ordanes 1 , Dominik Hajosi 1 , Fei Huang 1 , Brittany R Bhola 1 , Alina Iuga 1 , Tomoaki Kato 4 , Megan Sykes 1 and Adam D