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Mervyn Vergouwen: Bayer BV (investigator-initiated research, paid to instution) Poster Session II - INTRACRANIAL HEMORRHAGE 02.00 - INTRACRANIAL HEMORRHAGE - 02.01 - INTRACEREBRAL HAEMORRHAGE P770 - ESOC25-2045 TRACKING EARLY-DISEASE CHANGES IN DUTCH-TYPE HEREDITARY CAA: PRELIMINARY BASELINE RESULTS OF THE TRACK D-CAA STUDY Rosemarie van Dort 1 , Reinier van der Zwet 1 , Manon Schipper 1 , Neal Parikh 2 , Hamid Sohrabi 3 , Ralph Martins 4 , Steven Greenberg 5 , Marianne van Walderveen 1 , Matthias van Osch 1 , Marieke Wermer 6 1 Leiden University Medical Center, Leiden, Netherlands, 2 Alnylam Pharmaceuticals, Massachusetts, United States, 3 Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Perth, Australia, 4 Alzheimers Research Australia, & The Centre of Excellence for Alzheimers Disease Research and Care, Edith Cowan University, Perth, Australia, 5 Massachusetts General Hospital, Boston, United States, 6 University Medical Center Groningen, Groningen, Netherlands Background and Aims: This study aimed to investigate early disease biomarkers and natural history in D-CAA mutation-carriers and characterize disease progression over time

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For the detection of OCR of purified mitochondria from fresh liver tissues, an appropriate amount of mitochondria was resuspended in the mitochondrial storage solution containing the oxygen probe and seeded into a 96-well plate at 100 L per well