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Cost and Manufacturing Complexity The manufacturing costs of peptide drugs are generally higher than small molecule medications due to more complex synthesis or production processes

& Myers, E

bioRxiv2025 Nov 20

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The cause of AA remains unclear, although appendiceal lumen obstruction traditionally is accepted as the catalyst of a sequence of events that induces ischemia, necrosis, perforation, and ultimately peritonitis [12, 14, 29] (see Figure 1)