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The responses to formalin-induced pain, such as licking and biting of the injected paw, are biphasic

Common side effects include injection site reactions (pain, redness, swelling), gastrointestinal symptoms, and allergic reactions

Methionine is then converted into S-adenosylmethionine (SAM), which donates methyl groups in reactions catalyzed by methyltransferases, including DNA methylation, producing S-adenosylhomocysteine (SAH) that is converted back into homocysteine

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