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doi: 10.1038/ng.924 55 TedeschiPMPMJohnson-FarleyNLinHSheltonLMOogaTMackayGMGet al

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Concurrently, lactate accumulation contributes to an acidic tumor microenvironment that impairs T cell effector function, induces exhaustion, and suppresses proliferation [83]

Unlike earlier ghrelin mimetics such as GHRP-6, Ipamorelin demonstrates high selectivity for GH release without significantly elevating cortisol, prolactin, or ACTH

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Carriers of the Ala/Ala genotype have been associated with reduced psychological well-being, decreased responsiveness to levothyroxine therapy, and increased risk of hypothyroid symptoms despite normal serum TSH and T4 levels [82]