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Such cells contain major somatic mutations mentioned in humans such as BRCA1, phosphatase and PTEN, HER2, CDK, EGFR and p53

Homocysteine also triggers ROS generation and reduces the generation of nitric oxide (NO) with activation of inflammatory series leading to progressive neuronal loss (Hassin-Baer et al

Sahel JA, et al

Paula-Silva, Lcia H

Therefore, early intervention in replenishing mGSH stores by supplying GSH precursor such as N -acetylcysteine (NAC) or targeting upstream mechanisms involved in mitochondrial dysfunction and ROS generation, such as the sustained activation of c-Jun N-terminal kinases (JNK), can result in the protection of APAP-mediated hepatotoxicity

Traditionally, disease modeling relied on animal models or immortalized cell lines, both of which have limitations in recapitulating human disease due to differences in physiology, genetic makeup, and epigenetic regulation [553]