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Studies have shown that the PI3K/Akt signaling pathway plays an important role in multiple mechanisms of RA development, including angiogenesis, the proliferation, apoptosis and metastasis of FLS, and the expression of MMPs (43, 117, 153, 173), and it can also be considered as a potential target for the treatment of RA

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doi: 10.1007/BF02873539

Su uso en el embarazo puede producir anomalas congnitas debido a la alteracin del metabolismo del cido flico