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BCL-2 antagonist ABT-199 combined with complex I inhibitor IACS-010759 blocks mitochondrial respiration and facilitates anti-leukemia effect in pre-clinical AML models

Exact concentrations of the adjusted spike solutions are listed in Table S1

Retrieved April 22, 2026

This effect may be associated with the inhibition of the TGF-1/Smad2 pathway (87, 90, 94)

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coli BL21 Codon-Plus competent cells (New England Biolabs) and grown at 37 C in 2% Luria Broth containing 0.2% glucose and 100 mg/L ampicillin until OD 600 reached 0.30.37, at which point protein expression was induced with addition of 0.4 mM isopropyl -D-1-thiogalactopyranoside (IPTG)