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Though some antibacterial resistance was noted in patients on topical clindamycin as well as trimethoprim/sulfamethoxazole, no significant resistance was seen with oral tetracyclines or clindamycin

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Matrix of TME are also influenced by the consumption of glutamine leading to a decrease in energy supply required for T cells to perform immune functions, thereby suppressing their activity (266)

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To determine CNS penetrance, the levels of D and Q in CSF were measured using high-performance liquid chromatography with tandem mass spectrometry