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Lipo B12 injections bypass this step

The statistical analysis of the lipophilic fraction (Fig 2B and B) generated a weak OPLS-DA model with only limited class separation (with parameters R 2 = 0.56 and Q 2 = 0.28, CV-ANOVA test, P = 0.6), with a single metabolite (glycerophospholipidssphingomyelin) responsible for the class distinction (Figs 2B, B, and C and S3)

The missing piece might be vitamin b12

This depends on how severe the deficiency is and how well the patient responds to treatment

When foods containing B 12 are eaten, the vitamin is usually bound to protein and is released by proteases released by the pancreas into the small bowel