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Major risk factors for melasma include sun exposure, hormonal changes, genetics, and having a darker skin type

Functions as a for metabolic reaction required for synthesis of purines and pyrimidines: co-enzyme The reaction depends on methyl cobalamin as a co-factor and is also dependent on folate, in which the methyl group of methyltetrahydrofolate is transferred to homocysteine to form methionine and tetrahydrofolate

Its involved in: Energy production Hematopoiesis (red blood cell formation) DNA synthesis Brain development Nervous system function Fatty acid synthesis Myelin formation (5) The difference between vitamin B12 and the other B vitamins is its absorption pathway

There are several possible causes of vitamin B12 deficiency

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Congenital adrenocortical adenoma: case report and review of literature