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The elevated mechanical tension that resulted from a stiffened ECM diminished AT2 to AT1 differentiation and increased the abnormal accumulation of PATS

Instead, clinical success often depends on a balance between disease-relevant expression, pathway context, and the ability to achieve functional selectivity through dosing, delivery, or molecular mechanism

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These findings are in line with an earlier study reported by Antwi et al [51], who found that high -tocopherol levels are negatively linked to serum PSA concentrations in patients with recurrent prostate cancer

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