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We identified that Glutathione Peroxidase 3 (GPx3), a critical plasma-based antioxidant enzyme, was the sole protein examined that was both significantly and differentially abundant between affected and non-affected participants in both cohorts, with large reductions observed in those affected with konzo

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This immunomodulatory effect was mediated through the inhibition of phosphorylation of key NF-B signaling components, including IKK, IKK, and IB (264)

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& Gelvin, S