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We found that pharmacological MT1 and MT2 agonism failed to replicate the effects of melatonin in suppressing IL-5 production ( Figures 3B, D ) or IL-13 production ( Figures 3C, E )

& Aluru, S

However, despite these early observations about the metabolism of innate immune cells, it is only more recently that we have begun to elucidate the mechanisms behind these metabolic changes, and appreciate their impact on immune function