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Since the 1990s, clinical research has been carried out by a study group on the Ministry of Health, Labour and Welfare, suggested that ultrahigh-dose mecobalamin, which is respectively 50 and 100 times the approved dosage of Methycobal, could have a clinical effect in ALS, and Eisai then conducted the Phase II/III clinical trial (Study 761) from 2006

Nevertheless, supplementation with 2 mg/d folic acid, 25 mg/d vitamin B6, and 400 g/d B12 during 6 months significantly decreased the homocysteine levels, severity, and disability of migraine attacks (60)

While not a dedicated anti-dandruff treatment, many users report improved scalp health and reduced flaking within 4-6 weeks of regular use

At first glance, it may seem like higher oral doses would work better, but evidence suggests that is not always true

Older age : Due to changes in dietary nutrient intake (usually from eating less overall) and also decreased production of stomach acid, the elderly tend to have reduced levels of vitamin B12

Treatment duration differs significantly between the two options