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Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes

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In vitro fertilization was carried out in an incubator with 38.5C and 5% CO 2 concentration for 24 h

Future research can focus on using specific gene knockout/knock-in animal models and combining single-cell sequencing technology to clarify the spatiotemporal expression patterns and functional differences of p53 in different cell types (such as chondrocytes, synoviocytes, and osteoclasts) and different stages of OA

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