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Notably, Rab GTPases, which are substrates of LRRK2, play critical roles in SV trafficking

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Perhaps most critically, future efforts must focus on identifying and validating predictive biomarkers that can forecast response and resistance, including factors such as tumor mutational burden, the composition of the tumor microenvironment, and on-target antigen density

Diabetes mellitus (DM) is well known to boost the likelihood of developing several severe and potentially fatal health complications arising from the disruption and damage of organs such as the kidneys, heart, skin, blood vessels, and nerves