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An additional indicative point is sequential involvement

In some species, GH acts directly on androgen action, thereby accelerating the pubertal transition, because GH reduces the amount of testosterone required to induce secondary sexual characteristics (axillary hair) in young individuals [25]

Stoss et al

Instead, it modulates calcium channels in nerve cells, which helps calm nerve activity

Evaluating whether TQ-nanostructured lipid carrier (TQ-NLC) shows any toxic effect, Yazan and the team observed that after TQ-NLC administration (25 mg/kg, intravenous route), there was no visible change in the body weight, food intake, organ-to-body weight ratio, and hematological, biochemical, and histopathological profile, although an inflammation was marked at the injection site in rat tails [325]