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There is a growing body of evidence showing that mesenchymal stem cell therapy of female CBA/J mice protects fetuses from resorption in CBA/J x DBA/2 abortion model and induces Treg and Th2 type cytokines profile (8082).Considering that highly regenerative endometrial stroma harbors multipotent endometrial stem cells with properties and phenotype similar to bone marrow and adipose tissue MSC and possibly are responsible for regenerating the endometrial stroma in each menstrual cycle (83), it would be of utmost interest to investigate whether mesenchymal stem cell therapy in CBA/J mice could potentially affect decidualization

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10.1093/nar/gkr828 17

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For example, cisplatin induces mitochondrial calcium overload and oxidative stress, leading to mPTP opening and the release of pro-apoptotic factors