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Description

Following the Braak theory of ascending pathology from the brainstem towards the cortex, in the PD brain (Braak et al

(2016) 11:e0161571

Durcan, T

van Bunderen CC, van Nieuwpoort IC, van Schoor NM et al (2010) The association of serum insulin-like growth factor-I with mortality, cardiovascular disease, and cancer in the elderly: a population-based study

11), consistent with the scRNA-seq data

Pathway enrichment analysis suggested 23 key regulators of the CS response (Supplemental Table S5), including known factors like -catenin 36 , transforming growth factor 1 37 and KRAS 38 , while NUPR1, to the best of our knowledge, had not been described in the context of the airway epithelial response to CS (Fig