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Indomethacin, a potent inhibitor of 3a-hydroxysteroid dehydrogenase, a key enzyme responsible for the synthesis of allopregnanolone (ALLO) and tetradehydrodeoxycorticosterone (THDOC) (potent selective positive allosteric modulators of the GABA A receptors), has been shown to attenuate brain production of ALLO and THDOC and to improve activity in animals with CLF and mild HE [101]

Findings revealed that, in aged animals, the protrusions of PCs exhibited decreased contact with ECs, along with signs of vacuolization in ECs in C57BL/6 mice, as shown in Fig

These mice have normal respiratory frequency ( f R ) but display a higher tidal volume ( V T ) than control mice 9 (Fig

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A.GarciaA.Martin De ArgilaC.BoixedaD.et al (2004a)