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Knockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons

The majority of these adverse effects eventually go away without the need for medical intervention

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In particular, once an X chromosome is chosen for inactivation, extensive DNA methylation occurs on this chromosome, especially at CpG islands within promoter regions of genes, ensuring long-term gene silencing on the inactive X (Xi) chromosome

Lucerna M, Mechtcheriakova D, Kadl A, Schabbauer G, Schfer R, Gruber F, et al