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There is a wide variation in the reported prevalence of vitamin B12 deficiency in metformin users

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Strong CYP3A4 inhibitors may result in increased serum levels of trazodone

Testing for MMA and homocysteine levels is considered a more accurate reflection of usable B12

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In older children with mild disease, a 1 mg daily oral treatment regimen is suggested ( The different recommended doses, formulations and treatment schedules both between and within these countries highlight the important disparity in international clinical practice for the treatment of this heterogenous condition