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Description

Neuroinflammation was proposed by James Parkinson himself in the initial description of PD ( 2.1 Innate Immune Response Microglia are permanently in contact with astrocytes, neurons, and endothelial cells, constantly monitoring surrounding tissue for an ongoing infection or trauma via thin processes ( via the major histocompatibility complexes (MHC)-I and -II (48)

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However, omnivores who were put on a 6-month vegetarian diet did not reduce their muscle carnosine stores, suggesting carnosine homeostasis is tightly regulated and not entirely dependent on dietary intake (39)

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Multicenter clinical trials are essential to validate efficacy and safety, while personalized strategies based on patient-specific factors can achieve precision treatment and better outcomes

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