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The aim was to evaluate the effects of reduced methylation on FUS phase behavior

A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3

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This effect is likely to be mediated through several pathways: a) Upregulation of antioxidant enzymes: The significant increase in catalase levels observed in the IF group suggests that IF enhances endogenous antioxidant defenses, as catalase is a key enzyme in detoxifying hydrogen peroxide and mitigating oxidative stress

Alterations in histone acetylation and DNA methylation affect the transcription of key autophagy genes such as ATG5 and LC3B