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The OsAPX4 gene encoding peroxisomes in rice is thought is thought to affect plant development and resilience by regulating ROS signaling, suggesting that the peroxisome plays a significant role in maintaining ROS homeostasis in plant cells (Ribeiro et al., 2017)

However, the role of AMPK has been challenged and might only account for indirect changes in hepatic insulin sensitivity

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However, its clinical application is limited owing to oral toxicity, gastrointestinal toxicity, leukopenia and thrombocytopenia (75)

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Their modulation of the SIRT1/Nrf2/KEAP1 pathway along with reduced DNA fragmentation, has been observed to preserve renal histology when used as therapeutics against chromium and arsenic-induced nephrotoxicity