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Further studies demonstrated that Sinomenine exerted its core anti-tumor effect through inhibition of the PI3K-AKT-mTOR signaling pathway, manifested by downregulation of p-PI3K/PI3K, p-AKT/AKT, and mTOR expression, reduced AKT membrane translocation, and consequent suppression of pathway activity (255)

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Neurology 82:13621369 [DOI] [PubMed] [Google Scholar] El-Mezayen NS, Abd el Moneim RA, El-Rewini SH (2022) Vitamin B12 as a cholinergic system modulator and blood brain barrier integrity restorer in Alzheimers disease

Smart 131I labeled self-illuminating photosensitizers for deep tumor imaging guided therapy